EED226
CAS No. 2083627-02-3
EED226 ( EED226; EED-226; EED 226 )
产品货号. M17425 CAS No. 2083627-02-3
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥275 | 有现货 |
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5MG | ¥389 | 有现货 |
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10MG | ¥616 | 有现货 |
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25MG | ¥1021 | 有现货 |
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50MG | ¥1677 | 有现货 |
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100MG | ¥2989 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称EED226
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
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产品描述EED226 is a potent, selective, and orally bioavailable EED inhibitor. induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model. EED226 induces a conformational change upon binding EED, leading to loss of PRC2 activity. EED226 shows similar activity to SAM-competitive inhibitors in blocking H3K27 methylation of PRC2 target genes and inducing regression of human lymphoma xenograft tumors. Interestingly, EED226 also effectively inhibits PRC2 containing a mutant EZH2 protein resistant to SAM-competitive inhibitors. EED226 inhibits PRC2 activity via an allosteric mechanism and offers an opportunity for treatment of PRC2-dependent cancers. demonstrated very impressive antitumor activities in mouse xenograft model.
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同义词EED226; EED-226; EED 226
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通路Others
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靶点Other Targets
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受体EED; PRC2
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研究领域Cancer
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适应症——
化学信息
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CAS Number2083627-02-3
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分子量369.4
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分子式C17H15N5O3S
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纯度98%
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溶解度DMSO : ≥ 29 mg/mL. 78.51 mM; H2O : < 0.1 mg/mL
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SMILESc1(n2c(c(cn1)c1ccc(cc1)S(=O)(=O)C)nnc2)NCc1occc1
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化学全称N-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)[1,2,4]-triazolo[4,3-c]pyrimidin-5-amine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Huang Y, et al. J Med Chem. 2017 Mar 23;60(6):2215-2226.
产品手册
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