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EED226

CAS No. 2083627-02-3

EED226 ( EED226; EED-226; EED 226 )

产品货号. M17425 CAS No. 2083627-02-3

EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥275 有现货
5MG ¥389 有现货
10MG ¥616 有现货
25MG ¥1021 有现货
50MG ¥1677 有现货
100MG ¥2989 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    EED226
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
  • 产品描述
    EED226 is a potent, selective, and orally bioavailable EED inhibitor. induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model. EED226 induces a conformational change upon binding EED, leading to loss of PRC2 activity. EED226 shows similar activity to SAM-competitive inhibitors in blocking H3K27 methylation of PRC2 target genes and inducing regression of human lymphoma xenograft tumors. Interestingly, EED226 also effectively inhibits PRC2 containing a mutant EZH2 protein resistant to SAM-competitive inhibitors. EED226 inhibits PRC2 activity via an allosteric mechanism and offers an opportunity for treatment of PRC2-dependent cancers. demonstrated very impressive antitumor activities in mouse xenograft model.
  • 同义词
    EED226; EED-226; EED 226
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    EED; PRC2
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    2083627-02-3
  • 分子量
    369.4
  • 分子式
    C17H15N5O3S
  • 纯度
    98%
  • 溶解度
    DMSO : ≥ 29 mg/mL. 78.51 mM; H2O : < 0.1 mg/mL
  • SMILES
    c1(n2c(c(cn1)c1ccc(cc1)S(=O)(=O)C)nnc2)NCc1occc1
  • 化学全称
    N-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)[1,2,4]-triazolo[4,3-c]pyrimidin-5-amine

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Huang Y, et al. J Med Chem. 2017 Mar 23;60(6):2215-2226.
产品手册
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