• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

LDN-57444

CAS No. 668467-91-2

LDN-57444 ( Ubiquitin C-terminal Hydrolase L1 Inhibitor; UCH-L1 Inhibitor )

产品货号. M15554 CAS No. 668467-91-2

A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥275 有现货
5MG ¥413 有现货
10MG ¥745 有现货
25MG ¥1426 有现货
50MG ¥2535 有现货
100MG ¥3937 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    LDN-57444
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM.
  • 产品描述
    A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM; shows weak inhibition on Uch-L3 (IC50> 20 uM); causes cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate UPR.
  • 同义词
    Ubiquitin C-terminal Hydrolase L1 Inhibitor; UCH-L1 Inhibitor
  • 通路
    Proteasome/Ubiquitin
  • 靶点
    DUB
  • 受体
    UCH-L1;UCH-L3
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    668467-91-2
  • 分子量
    397.64
  • 分子式
    C17H11Cl3N2O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    O=C1N(CC2=CC(Cl)=CC=C2Cl)C3=C(C=C(Cl)C=C3)/C1=N/OC(C)=O
  • 化学全称
    1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Gong B, et al. Cell. 2006 Aug 25;126(4):775-88.
2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.
3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
产品手册
关联产品
  • USP10-IN-3

    USP10-IN-3 is a HBX19818 analog, potent and selective USP10 inhibitor, but does not inhibit USP7 (IC50>100 uM).

  • USP10-IN-9

    USP10-IN-9 is a HBX19818 analog, selective USP10 inhibitor with IC50 similar to HBX19818.

  • P-50429

    P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.