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LDN-57444
CAS No. 668467-91-2
LDN-57444 ( Ubiquitin C-terminal Hydrolase L1 Inhibitor; UCH-L1 Inhibitor )
产品货号. M15554 CAS No. 668467-91-2
A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥275 | 有现货 |
|
| 5MG | ￥413 | 有现货 |
|
| 10MG | ￥745 | 有现货 |
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| 25MG | ￥1426 | 有现货 |
|
| 50MG | ￥2535 | 有现货 |
|
| 100MG | ￥3937 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称LDN-57444
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM.
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产品描述A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM; shows weak inhibition on Uch-L3 (IC50> 20 uM); causes cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate UPR.
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同义词Ubiquitin C-terminal Hydrolase L1 Inhibitor; UCH-L1 Inhibitor
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通路Proteasome/Ubiquitin
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靶点DUB
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受体UCH-L1;UCH-L3
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number668467-91-2
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分子量397.64
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分子式C17H11Cl3N2O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C1N(CC2=CC(Cl)=CC=C2Cl)C3=C(C=C(Cl)C=C3)/C1=N/OC(C)=O
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化学全称1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Gong B, et al. Cell. 2006 Aug 25;126(4):775-88.
2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.
3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
2. Xie M, et al. J Alzheimers Dis. 2016;49(2):353-63.
3. Tan YY, et al. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
产品手册
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