HBX-19818 ( HBX19818; HBX-19818; HBX 19818 )

产品货号. M11802 CAS No. 1426944-49-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HBX-19818
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HBX-19818is apotent, selective USP7 inhibitor with IC50 of 28.1 uM.
产品描述

HBX-19818is apotent, selective USP7 inhibitor with IC50 of 28.1 uM; exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrests HCT116 cancer cells in G1.
同义词

HBX19818; HBX-19818; HBX 19818
通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

Cancer
适应症

——

CAS Number

1426944-49-1
分子量

421.96
分子式

C25H28ClN3O
纯度

>98% (HPLC)
溶解度

DMSO: 3.5 mg/mL; DMSO: 5.3 mg/mL (Need ultrasonic)
SMILES

O=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(C)CC4=CC=CC=C4
化学全称

2-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-

1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.

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