KS100

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KS100 是一种有效的 ALDH 抑制剂，对 ALDH1A1、ALDH2 和 ALDH3A1 的 IC50 分别为 334、2137、360 nM。KS100 具有低毒性的抗增殖和抗癌作用。KS100 显著增加 ROS 活性、脂质过氧化和有毒醛的积累。KS100 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。

KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase.

KS100 (compound 3j) (0-100 μM; 72 h) shows anti-proliferative activity with IC50s of 3.7, 2.1, 2.9, 2.5, 0.3, 1.0, 1.2, 1.3, 2.1, 9.8 μM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively.KS100 (5 μM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase.Apoptosis Analysis Cell Line:HCT116, HT29 cells Concentration:5 μM Incubation Time:24 h Result:Induced cell apoptosis.Apoptosis Analysis Cell Line:HCT116 cells Concentration:5 μM Incubation Time:24 hResult:Induced cell cycle arrest at G2/M phase.

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Metabolic Enzyme/Protease

Dehydrogenase

Dehydrogenase

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2408477-54-1

564.09

C17H14Br3N3O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (221.60 mM; 超声助溶 )

Br.O=C1C(=O)N(C=2C(Br)=CC(Br)=CC12)CC3=CC=C(C=C3)CSC(=N)N

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(-20℃)

With Ice Pack

≥ 2 years