G-749
CAS No. 1457983-28-6
G-749 ( alpha-MCPG )
产品货号. M17310 CAS No. 1457983-28-6
G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥632 | 有现货 |
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10MG | ¥1102 | 有现货 |
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25MG | ¥2519 | 有现货 |
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50MG | ¥4277 | 有现货 |
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200MG | ¥6602 | 有现货 |
|
500MG | ¥10044 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称G-749
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.
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产品描述G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. G-749 retained its inhibitory potency in various drug-resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. Furthermore, it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status, including those with little or only minor responses to AC220 or PKC412. Oral administration of G-749 yielded complete tumor regression and increased life span in animal models. Thus, G-749 appears to be a promising next-generation drug candidate for the treatment of relapsed and refractory AML patients with various FLT3-ITD/FLT3-TKD mutants and further shows the ability to overcome drug resistance.
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同义词alpha-MCPG
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体Aurora B; RET; FLT3; FLT3 (D835Y); Mer
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研究领域Cancer
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适应症——
化学信息
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CAS Number1457983-28-6
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分子量521.41
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分子式C25H25BrN6O2
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纯度98%
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溶解度DMSO : 25 mg/mL; 47.95 mM;
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SMILESCN1CCC(CC1)NC1=NC2=C(C(=O)NC=C2Br)C(NC2=CC=C(OC3=CC=CC=C3)C=C2)=N1
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化学全称8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lee HK, et al. Blood. 2014, 123(14), 2209-2219.
产品手册
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