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G-749

CAS No. 1457983-28-6

G-749 ( alpha-MCPG )

产品货号. M17310 CAS No. 1457983-28-6

G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.

纯度: 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥632 有现货
10MG ¥1102 有现货
25MG ¥2519 有现货
50MG ¥4277 有现货
200MG ¥6602 有现货
500MG ¥10044 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    G-749
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.
  • 产品描述
    G-749 is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. G-749 retained its inhibitory potency in various drug-resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. Furthermore, it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status, including those with little or only minor responses to AC220 or PKC412. Oral administration of G-749 yielded complete tumor regression and increased life span in animal models. Thus, G-749 appears to be a promising next-generation drug candidate for the treatment of relapsed and refractory AML patients with various FLT3-ITD/FLT3-TKD mutants and further shows the ability to overcome drug resistance.
  • 同义词
    alpha-MCPG
  • 通路
    Metabolic Enzyme/Protease
  • 靶点
    Dehydrogenase
  • 受体
    Aurora B; RET; FLT3; FLT3 (D835Y); Mer
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1457983-28-6
  • 分子量
    521.41
  • 分子式
    C25H25BrN6O2
  • 纯度
    98%
  • 溶解度
    DMSO : 25 mg/mL; 47.95 mM;
  • SMILES
    CN1CCC(CC1)NC1=NC2=C(C(=O)NC=C2Br)C(NC2=CC=C(OC3=CC=CC=C3)C=C2)=N1
  • 化学全称
    8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Lee HK, et al. Blood. 2014, 123(14), 2209-2219.
产品手册
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