Inecalcitol
CAS No. 163217-09-2
Inecalcitol ( TX-522; TX 522; TX522 )
产品货号. M27771 CAS No. 163217-09-2
Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥6278 | 有现货 |
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5MG | ¥9639 | 有现货 |
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10MG | ¥12879 | 有现货 |
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25MG | ¥19359 | 有现货 |
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50MG | ¥26082 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Inecalcitol
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.
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产品描述Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.(In Vitro):A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow.(In Vivo):Inecalcitol maximal tolerated dose (MTD) by intraperitoneal (i.p.) administration was 30 μg/mouse (1,300 μg/kg) three times per week, while we previously found that the MTD of 1,25(OH)(2) D(3) is 0.0625 μg/mouse; therefore, inecalcitol is 480 times less hypercalcemic than 1,25OH2 D3. Inecalcitol inhibits androgen-responsive prostate cancer growth in vivo.
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同义词TX-522; TX 522; TX522
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通路Apoptosis
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靶点Apoptosis
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受体HIPK2
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研究领域——
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适应症——
化学信息
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CAS Number163217-09-2
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分子量400.6
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分子式C26H40O3
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纯度>98% (HPLC)
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溶解度——
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SMILESC[C@H](CC#CC(C)(C)O)[C@H]1CC[C@@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C[C@H](O)C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ruijie Liu, et al. A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF-β1/Smad3 Pathway. J Am Soc Nephrol. 2017 Feb 20. pii: ASN.2016080841.
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