ASK1-IN-2
CAS No. 2541792-70-3
ASK1-IN-2 ( —— )
产品货号. M28644 CAS No. 2541792-70-3
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis.
纯度: >98% (HPLC)
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1725 | 有现货 |
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10MG | ¥2778 | 有现货 |
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25MG | ¥4722 | 有现货 |
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50MG | ¥6764 | 有现货 |
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100MG | ¥9315 | 有现货 |
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500MG | ¥18549 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称ASK1-IN-2
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis.
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产品描述ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a therapeutic strategy for ulcerative colitis.(In Vitro):ASK1-IN-2 displays potent anti-ASK1 kinase activity and strong inhibitory effect on ASK1 in AP1-HEK293 cells with inhibition rate of 95.59%.(In Vivo):ASK1-IN-2 (1 mg/kg; i.v.) shows low clearance (CL=1.38 L/h/kg) and moderate half-life (T1/2=1.45 h) in rats. ASK1-IN-2 (10 mg/kg; p.o.) shows high oral exposure (AUClast=4517 h?ng/mL), 62.2% oral bioavailability and acceptable terminal half-life (T1/2=2.31 h) in rats. ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) improves dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice. ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) blocks ASK1-p38/JNK signaling pathways and reduces inflammatory cytokine levels in DSS-induced mouse colon tissues.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体PLK2;PLK3;PLK1
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研究领域——
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适应症——
化学信息
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CAS Number2541792-70-3
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分子量364.4
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分子式C19H17FN6O
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)n1c(-c2cccc(NC(c3cc(ccc(F)c4)c4[nH]3)=O)n2)nnc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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K145 hydrochloride
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 μM and Ki of 6.4 μM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
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Triglycidyl isocyanu...
Triglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research.
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Silvestrol aglycone
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.