Gliotoxin
CAS No. 67-99-2
Gliotoxin ( Aspergillin )
产品货号. M29154 CAS No. 67-99-2
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2827 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Gliotoxin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
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产品描述Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.(In Vitro):Incubation of the cells for 10min with 30-100ng/ml of Gliotoxin inhibited phagocytosis of either zymosan or serum-opsonized zymosan without affecting superoxide production or the exocytosis of specific and azurophil granules. Gliotoxin exhibited anti-tuberculosis activity towards Mycobacterium tuberculosis with the prominent MIC50?values of <0.03 μM.
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同义词Aspergillin
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis
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研究领域——
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适应症——
化学信息
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CAS Number67-99-2
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分子量326.4
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分子式C13H14N2O4S2
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纯度>98% (HPLC)
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溶解度——
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SMILESCN([C@]1(CO)SS[C@@]2(CC([C@H]34)=CC=C[C@@H]4O)N3C1=O)C2=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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