CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.

Amperozide, a 5-HT2 antagonist, attenuates craving for cocaine by rats and reduces agonistic behaviors such as slashing and biting in pigs.

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has a selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.