FT895 ( FT 895;FT-895 )

产品货号. M13554 CAS No. 2225728-57-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

FT895
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FT895 (FT-895) is a potent and selective inhibitor of HDAC11 with IC50 of 3 nM.
产品描述

FT895 (FT-895) is a potent and selective inhibitor of HDAC11 with IC50 of 3 nM, displays no significant activity against HDAC1-10 (IC50>5 uM); displays promising cellular activity (IC50<20 nM) and pharmacokinetic properties; FT895 is a useful tool to study the biology of HDAC11 and shows potential use as a therapeutic target for oncology and inflammation indications.
同义词

FT 895;FT-895
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC
研究领域

——
适应症

——

CAS Number

2225728-57-2
分子量

352.32
分子式

C16H15F3N4O2
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(NO)C1=C(CN(C2=CN=C(C(F)(F)F)C=N2)C3(C)C)C3=CC=C1
化学全称

N-hydroxy-1,1-dimethyl-2-(5-(trifluoromethyl)pyrazin-2-yl)isoindoline-4-carboxamide

1. Martin MW, et al. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2143-2147.

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