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CHDI-390576
CAS No. 1629729-98-1
CHDI-390576 ( CHDI390576 )
产品货号. M12446 CAS No. 1629729-98-1
CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CHDI-390576
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor.
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产品描述CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor with IC50 of 54/60/31/50 nM for HDAC4/5/7/9, respectively; displays >500-fold selectivity over class I HDAC/1/2/3 and 150-fold selectivity over HDAC8 and the class IIb HDAC6; CHDI-390576 was well-tolerated and showed no significant effect on passive observations, responses to manipulations, body weight, or body temperature in PK studies.
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同义词CHDI390576
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域——
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适应症——
化学信息
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CAS Number1629729-98-1
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分子量391.33
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分子式C19H13F4N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NO)C(C1=CC=CC=C1F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2
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化学全称2-(2-fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Luckhurst CA, et al. Bioorg Med Chem Lett. 2018 Nov 13. pii: S0960-894X(18)30858-8. doi: 10.1016/j.bmcl.2018.11.009.
产品手册
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