SW-100

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3 nM.

SW-100 (SW100) is a potent, selective, brain penetrable HDAC6 inhibitor with IC50 of 2.3 nM, displays >1,000-fold selectivity over all other class I, II, and IV HDAC isoforms; selectively inhibits HDAC6-CD2 and enhances α-tubulin acetylation in cells with no effect on histone acetylation and selectively restores the impaired acetylated α-tubulin levels in the hippocampus of Fmr1-/- mice; ameliorates several memory and learning impairments in Fmr1-/- mice, thus modeling the intellectual deficiencies associated with Fragile X syndrome (FXS).

SW100;SW 100

Cell Cycle/DNA Damage

HDAC

HDAC

——

——

2126744-35-0

316.79

C17H17ClN2O2

>98% (HPLC)

DMSO : ≥ 125 mg/mL 394.60 mM

C1CC2=C(C=CC(=C2)Cl)N(C1)CC3=CC=C(C=C3)C(=O)NO

4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide

(-20℃)

With Ice Pack

≥ 2 years