FT-827 ( FT827;FT 827 )

产品货号. M13071 CAS No. 1959537-86-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

FT-827
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
产品描述

A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain); modifies the catalytic Cys223 of USP7 and inhibits the enzyme with kinact/Ki of 66 M-1s-1, display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs)
同义词

FT827;FT 827
通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

Cancer
适应症

——

CAS Number

1959537-86-0
分子量

548.62
分子式

C27H28N6O5S
纯度

>98% (HPLC)
溶解度

DMSO : 125 mg/mL 227.85 mM
SMILES

O=C(N1CCC(O)(CN2C=NC(N(C)N=C3)=C3C2=O)CC1)C(C=C4)=CC=C4C5=CC=CC=C5NS(C=C)(=O)=O
化学全称

N-(4'-(4-hydroxy-4-((1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl)piperidine-1-carbonyl)-[1,1'-biphenyl]-2-yl)ethenesulfonamide

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.

计算器

产品手册

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