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FT-827

CAS No. 1959537-86-0

FT-827 ( FT827;FT 827 )

产品货号. M13071 CAS No. 1959537-86-0

A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥7857 有现货
50MG ¥16038 有现货
100MG ¥20250 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    FT-827
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain).
  • 产品描述
    A novel potent, specific, covalent USP7 inhibitor with Kd of 7.8 uM (USP7 catalytic domain); modifies the catalytic Cys223 of USP7 and inhibits the enzyme with kinact/Ki of 66 M-1s-1, display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs)
  • 同义词
    FT827;FT 827
  • 通路
    Proteasome/Ubiquitin
  • 靶点
    DUB
  • 受体
    DUB
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1959537-86-0
  • 分子量
    548.62
  • 分子式
    C27H28N6O5S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 125 mg/mL 227.85 mM
  • SMILES
    O=C(N1CCC(O)(CN2C=NC(N(C)N=C3)=C3C2=O)CC1)C(C=C4)=CC=C4C5=CC=CC=C5NS(C=C)(=O)=O
  • 化学全称
    N-(4'-(4-hydroxy-4-((1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)methyl)piperidine-1-carbonyl)-[1,1'-biphenyl]-2-yl)ethenesulfonamide

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.
产品手册
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