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Elacestrant
CAS No. 722533-56-4
Elacestrant ( RAD-1901 )
产品货号. M15763 CAS No. 722533-56-4
Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2811 | 有现货 |
|
| 10MG | ￥4026 | 有现货 |
|
| 25MG | ￥6423 | 有现货 |
|
| 50MG | ￥9153 | 有现货 |
|
| 100MG | ￥12312 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Elacestrant
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD).
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产品描述Elacestrant (RAD-1901) is a novel, orally bioavailable small-molecule selective estrogen receptor degrader (SERD); inhibits ERα expression in MCF-7 cells (IC50=0.6 nM); induces the degradation of ER, inhibits ER-mediated signaling and growth of ER+ breast cancer cell lines in vitro and in vivo, and significantly inhibits tumor growth of multiple PDX models.Breast Cancer Phase 2 Clinical
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同义词RAD-1901
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体Estrogen Receptor/ERR
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研究领域Cancer
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适应症Breast Cancer
化学信息
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CAS Number722533-56-4
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分子量458.63
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分子式C30H38N2O2
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纯度>98% (HPLC)
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溶解度DMSO
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SMILESCCNCCC1=CC=C(C=C1)CN(CC)C2=C(C=CC(=C2)OC)C3CCC4=C(C3)C=CC(=C4)O
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化学全称2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, (6R)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wardell SE, et al. Endocr Relat Cancer. 2015 Oct;22(5):713-24.
2. Garner F, et al. Anticancer Drugs. 2015 Oct;26(9):948-56.
3. Bihani T, et al. Clin Cancer Res. 2017 May 4. pii: clincanres.2561.2016.
2. Garner F, et al. Anticancer Drugs. 2015 Oct;26(9):948-56.
3. Bihani T, et al. Clin Cancer Res. 2017 May 4. pii: clincanres.2561.2016.
产品手册
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