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Diazoxide
CAS No. 364-98-7
Diazoxide ( NSC 64198 | NSC 76130 | SRG 95213 )
产品货号. M14255 CAS No. 364-98-7
二氮嗪是一种钾通道激活剂，通过增加膜对钾离子的通透性导致平滑肌局部松弛。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | ￥405 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Diazoxide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述二氮嗪是一种钾通道激活剂，通过增加膜对钾离子的通透性导致平滑肌局部松弛。
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产品描述Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions.(In Vitro):Diazoxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia.Diazoxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage. (In Vivo):Diazoxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels.Treatment with Diazoxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg.
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体外实验——
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体内实验——
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同义词NSC 64198 | NSC 76130 | SRG 95213
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通路Endocrinology/Hormones
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靶点ATPase
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受体Na+/K+-ATPase| Potassium Channel
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研究领域Cardiovascular Disease
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适应症——
化学信息
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CAS Number364-98-7
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分子量230.67
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分子式C8H7ClN2O2S
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纯度>98% (HPLC)
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溶解度Soluble in DMSO
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SMILESCC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.D’hahan N, et al. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12162-7.
