DS-6051b ( Taletrectinib,AB-106 )

产品货号. M22510 CAS No. 1505515-69-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

DS-6051b
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.DS-6051b inhibited the growth of the ROS1 fusion-positive HCC78 cancer cell line and the CD74-ROS1 overexpressed Ba/F3 cells.
产品描述

DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.DS-6051b inhibited the growth of the ROS1 fusion-positive HCC78 cancer cell line and the CD74-ROS1 overexpressed Ba/F3 cells. DS-6051b potently inhibited autophosphorylation of ROS1 in the SLC34A2-ROS1 harboring HCC78 cells and CD74-ROS1-expressed Ba/F3 cells at approximately single-digit to double-digit nanomolar concentration.DS-6051b induced tumor shrinkage at a ≥50mg/kg in vivo experiments using the KM12-bearing mouse xenograft model or higher treatment dose without significant body weight loss.
同义词

Taletrectinib,AB-106
通路

Immunology/Inflammation
靶点

ROS
受体

ROS1; TrkA; TrkB; TrkC
研究领域

——
适应症

——

CAS Number

1505515-69-4
分子量

551.61
分子式

C29H34FN5O5
纯度

>98% (HPLC)
溶解度

DMSO:50 mg/ml (90.64 mM)
SMILES

OC(=O)CCCCC(O)=O.C[C@@H](N)COc1ccc(cc1)-c1cnc2ccc(N[C@H](C)c3cccc(F)c3)nn12
化学全称

——

1. Katayama R,et al.Nat Commun. 2019 9;10(1):3604.

计算器

产品手册

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Dihydrotanshinone I

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2,8-Quinolinediol

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