DHODH-IN-12 ( —— )

产品货号. M32884 CAS No. 1263303-93-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

DHODH-IN-12
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

DHODH-IN-12 (Compound 12b) 是一种 Leflunomide 衍生物，也是一种二氢乳清酸脱氢酶 (DHODH) 的弱抑制剂，其 pKa 为 5.07。
产品描述

DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of5.07.
体外实验

Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 12a), is designed. Compound 12a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-12 (Compound 12b). DHODH-IN-12 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure.
体内实验

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同义词

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通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

Dehydrogenase
研究领域

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适应症

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1. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.?

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