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DHODH-IN-1
CAS No. 1800296-63-2
DHODH-IN-1 ( —— )
产品货号. M26153 CAS No. 1800296-63-2
DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2373 | 有现货 |
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| 5MG | ￥3637 | 有现货 |
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| 10MG | ￥5338 | 有现货 |
|
| 25MG | ￥7995 | 有现货 |
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| 50MG | ￥11259 | 有现货 |
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| 100MG | ￥15228 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称DHODH-IN-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM.
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产品描述DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.(In Vitro):DHODH-IN-1 (4-100 nM) prevents the measles virus from replicating in cells. When transfecting cells with ssRNA molecules, DHODH-IN-1 (0.008-5 μM) can increase the expression of ISRE luciferase reporter gene. DHODH-IN-1 inhibits Jurkat cell proliferation with an IC50 value of 0.02 μM.(In Vivo):The t1/2 for DHODH-IN-1 is 27–41 min.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体N-acylethanolamine acid amidase (NAAA)
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研究领域——
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适应症——
化学信息
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CAS Number1800296-63-2
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分子量403.4
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分子式C21H20F3N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)Oc1nn(c(C)c1Oc1c(F)cccc1F)-c1ncc(cc1F)C1CC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Yannick Fotio, et al. Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models. J Pharmacol Exp Ther. 2021 Aug;378(2):70-76.
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