CeMMEC1 ( CeMMEC 1 )

产品货号. M14499 CAS No. 440662-09-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

CeMMEC1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CeMMEC1 is a potent, selective second bromodomain of TAF1 inhibitor with Kd of 1.8 uM.
产品描述

CeMMEC1 is a potent, selective second bromodomain of TAF1 inhibitor with Kd of 1.8 uM; shows high selectivity for the TAF1 (2) bromodomain over BRD4 (1), BRD9, CREBBP, EP300 and TAF1 (2) bromodomains (IC50>10 uM; impaires cell viability in TAF1 downregulated cells; synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.
同义词

CeMMEC 1
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

BRD4;TAF1
研究领域

——
适应症

——

CAS Number

440662-09-9
分子量

336.30
分子式

C19H16N2O4
纯度

>98% (HPLC)
溶解度

DMSO: 21 mg/mL (62.4 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CN1C=C(C2=CC=CC=C2C1=O)C(=O)NC3=CC4=C(C=C3)OCCO4
化学全称

N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide

1. Sdelci S, et al. Nat Chem Biol. 2016 Jul;12(7):504-10.

计算器

产品手册

关联产品

GSK-6853

A potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1.
NI-42

A potent, selective and orally active BRPF1 bromodomain inhibitor with IC50 of 7.9 nM.
XDM-CBP

A highly potent and selective inhibitor of CBP/p300 bromodomain with Kd of 0.23/0.47 uM respectively.