Ischemin ( —— )

产品货号. M11461 CAS No. 1357059-00-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

Ischemin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A cell permeable CBP bromodomain inhibitor with Kd of 19 uM.
产品描述

A cell permeable CBP bromodomain inhibitor with Kd of 19 uM; inhibits the acetyl-lysine binding activity of CBP, inhibits p53 interaction with CBP and decreases p53 transcriptional activity; protects against doxorubicin-induced apoptosis in cardiomyocytes in vitro.
同义词

——
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1357059-00-7
分子量

335.38
分子式

C15H17N3O4S
纯度

>98% (HPLC)
溶解度

——
SMILES

CC1=CC(=C(C=C1N=NC2=C(C=C(C(=C2)C)O)N)S(=O)(=O)O)C
化学全称

5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid

1. Borah JC, et al. Chem Biol. 2011 Apr 22;18(4):531-41.

计算器

产品手册

关联产品

BAY-850

BAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay.
I-BRD9

The first selective cellular chemical probe for BRD9 with pIC50 of 7.3.
ZL0454

ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.