CaCCinh-A01 ( CaCCinh-A01; CaCC(inh)-A01, TMEM16 Blocker I )

产品货号. M17503 CAS No. 407587-33-1

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Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CaCCinh-A01
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
产品描述

CaCCinh-A01, also known as TMEM16 Blocker I, is a TMEM16 Blocker. CaCCinh-A01 is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 μM).
同义词

CaCCinh-A01; CaCC(inh)-A01, TMEM16 Blocker I
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

TMEM16A;CaCC
研究领域

——
适应症

——

CAS Number

407587-33-1
分子量

347.43
分子式

C18H21NO4S
纯度

98%
溶解度

DMSO : ≥ 50 mg/mL; 143.91 mM
SMILES

CC(C)(C)C1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C3=CC=CO3
化学全称

6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

1.Namkung W,etal. J Biol Chem. 2011 Jan 21;286(3):2365-74.

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