Zolmitriptan

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

佐米曲普坦是一种选择性血清素受体激动剂。

Zolmitriptan is a selective serotonin receptor agonist.(In Vitro):Zolmitriptan (311C90) exhibits higher affinity to 5-HT than sumatriptan (pKA=6.63±0.04 and 6.16±0.03, respectively). 311C90 displays high affinity at human recombinant 5-HT1D and 5-HT1B receptors in transfected CHO-K1 cell membranes (pIC50 values=9.16±0.12 and 8.32±0.09, respectively) .(In Vivo):Zolmitriptan (311C90; 3-30 μg/kg, i.v.) causes a dose-dependent inhibition of [125I]-albumin extravasation within the ipsilateral dura mater. Zolmitriptan also produces dose-dependent falls in cranial vascular conductance (32.3% at 30 μg/kg). Zolmitriptan is an anti-migraine agent with action at 5-HT1B/D receptors. Zolmitriptan is an effective and behaviorally specific anti-aggressive agent in situations that engender moderate and alcohol-heightened levels of aggression. Zolmitriptan (1-30 mg/kg, i.p.) exerts behaviorally specific anti-aggressive effects in mice."

Zolmitriptan (311C90) exhibits higher affinity to 5-HT than sumatriptan (pKA=6.63±0.04 and 6.16±0.03, respectively). 311C90 displays high affinity at human recombinant 5-HT1D and 5-HT1B receptors in transfected CHO-K1 cell membranes (pIC50 values=9.16±0.12 and 8.32±0.09, respectively) .

Zolmitriptan (311C90; 3-30 μg/kg, i.v.) causes a dose-dependent inhibition of [125I]-albumin extravasation within the ipsilateral dura mater. Zolmitriptan also produces dose-dependent falls in cranial vascular conductance (32.3% at 30 μg/kg).Zolmitriptan is an anti-migraine agent with action at 5-HT1B/D receptors. Zolmitriptan is an effective and behaviorally specific anti-aggressive agent in situations that engender moderate and alcohol-heightened levels of aggression. Zolmitriptan (1-30 mg/kg, i.p.) exerts behaviorally specific anti-aggressive effects in mice. Animal Model:Anaesthetized guinea-pigs.

BW 311C90 | Zomig

Endocrinology/Hormones

5-HT Receptor

5-HT

Neurological Disease

——

139264-17-8

287.36

C16H21N3O2

>98% (HPLC)

Ethanol: 58 mg/mL (201.83 mM); DMSO: 58 mg/mL (201.83 mM)

O=C1OC[C@H](CC2=CC3=C(NC=C3CCN(C)C)C=C2)N1

(4S)-4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one

(-20℃)

With Ice Pack

≥ 2 years