CPI-637 ( CPI637;CPI 637 )

产品货号. M12946 CAS No. 1884712-47-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CPI-637
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM.
产品描述

A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM; displays >700-fold selectivity over the BET bromodomains (BRD4 IC50=11.0 uM), also highly selective against other bromodomains; inhibits the expression of MYC with an EC50 of 0.60 uM in a cellular assay.
同义词

CPI637;CPI 637
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

BRD4;CBP;EP300
研究领域

Cancer
适应症

——

CAS Number

1884712-47-3
分子量

386.45
分子式

C22H22N6O
纯度

>98% (HPLC)
溶解度

DMSO
SMILES

CN(N=C1C2=CN(C)N=C2)C3=C1C=C(C4=CC=CC(N5)=C4N[C@H](C)CC5=O)C=C3
化学全称

2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-

1. Taylor AM, et al. ACS Med Chem Lett. 2016 Mar 15;7(5):531-6.

计算器

产品手册

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