L-45
CAS No. 2079885-05-3
L-45 ( PCAF BRD inhibitor L-45 )
产品货号. M13235 CAS No. 2079885-05-3
PCAF BRD inhibitor L-45 is a potent, selective, and cell-active PCAF bromodomain inhibitor with Ki of 47 nM in HTRF assays.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2284 | 有现货 |
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50MG | ¥9477 | 有现货 |
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100MG | ¥14337 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称L-45
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述PCAF BRD inhibitor L-45 is a potent, selective, and cell-active PCAF bromodomain inhibitor with Ki of 47 nM in HTRF assays.
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产品描述PCAF BRD inhibitor L-45 is a potent, selective, and cell-active PCAF bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4; disrupt PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, shows high selectivity for PCAF and GCN5 bromodomain (Kd=600 nM); shows no observable cytotoxicity in PBMCs, good cell-permeability, and metabolic stability in human and mouse liver microsomes.
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同义词PCAF BRD inhibitor L-45
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通路Chromatin/Epigenetic
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靶点Bromodomain
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受体Bromodomain
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研究领域Cancer
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适应症——
化学信息
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CAS Number2079885-05-3
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分子量360.47
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分子式C21H24N6
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纯度>98% (HPLC)
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溶解度——
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SMILESC[C@H](NC(C1=C2C=CC=C1)=NN3C2=NN=C3C)[C@H](C4=CC=CC=C4)N(C)C
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化学全称(1S,2S)-N1,N1-dimethyl-N2-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Moustakim M, et al. Angew Chem Int Ed Engl. 2017 Jan 16;56(3):827-831.
产品手册
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