CK-0106023 ( CK 0106023;CK0106023 )

产品货号. M14141 CAS No. 336115-72-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CK-0106023
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM.
产品描述

A potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM; displays >200-fold selectivity over the mitotic kinesins CENP-E, MKLP1 and Kif1A; causes mitotic arrest and growth inhibition in several human tumor cell lines; exhibits antitumor activity in tumor-bearing mice.
同义词

CK 0106023;CK0106023
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

Kinesin
研究领域

——
适应症

——

CAS Number

336115-72-1
分子量

595.96
分子式

C30H32BrClN4O2
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(N(C(C(N1CC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC)CCCN(C)C)C4=CC=C(Br)C=C4
化学全称

N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)propyl)-4-bromo-N-(3-(dimethylamino)propyl)benzamide

1. Sakowicz R, et al. Cancer Res. 2004 May 1;64(9):3276-80.
2. Zhang B, et al. Anal Biochem. 2005 Oct 15;345(2):326-35.

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产品手册

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