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CBR-5884
CAS No. 681159-27-3
CBR-5884 ( —— )
产品货号. M22643 CAS No. 681159-27-3
CBR-5884 is an ?selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM.?CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.?
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥316 | 有现货 |
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| 5MG | ￥510 | 有现货 |
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| 10MG | ￥786 | 有现货 |
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| 25MG | ￥1847 | 有现货 |
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| 50MG | ￥3200 | 有现货 |
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| 100MG | ￥4771 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CBR-5884
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CBR-5884 is an ?selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM.?CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.?
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产品描述CBR-5884 is an ?selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM.?CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity.?CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis.?Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDHCBR-5884 (15 or 30 μM; 3-5 days) selectively inhibits breast cancer lines that have a high propensity for serine synthesis. CBR-5884 (15 or 30 μM; 3-5 days) also selectively inhibits the proliferation of melanoma.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体PHGDH;serine synthesis
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研究领域——
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适应症——
化学信息
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CAS Number681159-27-3
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分子量336.39
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分子式C14H12N2O4S2
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纯度>98% (HPLC)
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溶解度DMSO:47 mg/mL (139.72 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
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SMILESCCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Proc Natl Acad Sci U S A, 2016 Feb 16, 113(7):1778-83.
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