Bufalin ( NSC 89595 )

产品货号. M14561 CAS No. 465-21-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Bufalin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu.
产品描述

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
同义词

NSC 89595
通路

Endocrinology/Hormones
靶点

ATPase
受体

Na+/K+-ATPase
研究领域

Cancer
适应症

——

CAS Number

465-21-4
分子量

386.52
分子式

C24H34O4
纯度

>98%(HPLC)
溶解度

DMSO: 10 mM
SMILES

5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
化学全称

5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one

1.Chen YY, et al. Environ Toxicol. 2015 Jan;30(1):74-82.

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