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Brigatinib
CAS No. 1197953-54-0
Brigatinib ( AP-26113;AP26113 )
产品货号. M10706 CAS No. 1197953-54-0
Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥348 | 有现货 |
|
| 10MG | ￥494 | 有现货 |
|
| 25MG | ￥753 | 有现货 |
|
| 50MG | ￥940 | 有现货 |
|
| 100MG | ￥1369 | 有现货 |
|
| 200MG | ￥2049 | 有现货 |
|
| 500MG | ￥3467 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Brigatinib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM.
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产品描述Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM, exhibits about fivefold greater potency in vitro compared with crizotinib; shows high activity against both sensitive and resistant H3122 cells, decreasing cell growth, suppressing ALK phosphorylation, and inducing apoptosis; AP26113 is also active in Ba/F3 cells expressing either native or mutant EML4-ALK with IC50 of 10 and 24 nM, respectively; demonstrates promising activity in crizotinib resistant.Lung Cancer Approved
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同义词AP-26113;AP26113
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通路Angiogenesis
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靶点ALK
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受体ALK;EGFR(C797S/del19);FLT3;IGF-1R;ROS1
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研究领域Cancer
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适应症Lung Cancer
化学信息
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CAS Number1197953-54-0
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分子量584.09
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分子式C29H39ClN7O2P
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纯度>98% (HPLC)
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溶解度10 mM in Ethanol
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SMILESCN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC
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化学全称2,4-Pyrimidinediamine, 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
2. Ceccon M, et al. Mol Cancer Res. 2013 Feb;11(2):122-32.
3. Ceccon M, et al. Mol Cancer Res. 2015 Apr;13(4):775-83.
4. Fontana D, et al. Cancer Med. 2015 Jul;4(7):953-65.
产品手册
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Brigatinib
Brigatinib (AP-26113, AP26113) is a potent, selective, second generation ALK inhibitor with IC50 of 0.62 nM.
