Bis-T-23

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bis-T-23 是一种小分子，可刺激肌动蛋白依赖性动力蛋白寡聚化并促进动力蛋白 GTP 酶活性。

Bis-T-23 is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes; ameliorates or prevents proteinuria and diminishes mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents, improves renal health in diverse models of both transient kidney disease and CKD.

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Animal Model:Sprague-Dawley rats (8 weeks old, males); Mice Dosage:20, 40 mg/kg; 40 mg/kg Administration:Intraperitoneal injection; signle, once for 6 consecutive days Result:Specifically reduced proteinuria on days 18 and 24.Caused a transient reduction of proteinuria (single dose) in PKCε KOmice.Completely prevented the onset of high-level proteinuria in the CD2AP KOmice.Significantly extended the lifespans of CD2AP KOmice.Led to improved glomerular histology with less mesangial matrix accumulation.Animal Model:ZebrafishDosage:1 ng Administration:Injection Result:Promoted oligomerization of zebrafish Dyn2.Increased the number of focal adhesions (FAs) and stress fibers in cultured podocytes.

Ryngo 1-23

Cytoskeleton/Cell Adhesion Molecules

Dynamin

Dynamin

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171674-76-3

480.433

C23H20N4O8

>98% (HPLC)

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O=C(NCCCNC(/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1)=O)/C(C#N)=C/C2=CC(O)=C(O)C(O)=C2

(2E,2'E)-N,N'-1,3-Propanediylbis[2-cyano-3-(3,4,5-trihydroxyphenyl)-2-propenamide]

(-20℃)

With Ice Pack

≥ 2 years