BRD5631 ( BRD 5631;BRD-5631 )

产品货号. M16938 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

BRD5631
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A small-molecule enhancer of autophagy through an mTOR-independent pathway; significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs.
产品描述

A small-molecule enhancer of autophagy through an mTOR-independent pathway; significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs; significantly reduces levels of endogenous p62 and cell death in NPC1 hiPSC-derived neurons; enhances bacterial clearance and suppresses IL-1β Secretion in an autophagy-dependent manner; a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease.
同义词

BRD 5631;BRD-5631
通路

Autophagy
靶点

Autophagy
受体

Autophagy
研究领域

——
适应症

——

CAS Number

——
分子量

501.63
分子式

C30H35N3O4
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(NC(C=C1)=CC2=C1OC[C@H](C)NC[C@H](C)[C@H](OC)CN(C)C2=O)C3=CC=C(C4=CC=CC=C4)C=C3
化学全称

N-((3S,6S,7S)-7-methoxy-3,6,9-trimethyl-10-oxo-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1]oxa[4,9]diazacyclododecin-12-yl)-[1,1'-biphenyl]-4-carboxamide

1. Kuo SY, et al. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7.

计算器

产品手册

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