Oleandrin ( PBI05204; PBI 05204; PBI-05204; Oleandrin )

产品货号. M18570 CAS No. 465-16-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

Oleandrin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Oleandrin, the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels.
产品描述

Oleandrin, also known as PBI-05204 , is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically binds to and inhibits the alpha3 subunit of the Na/K-ATPase pump in human cancer cells. This may inhibit the phosphorylation of Akt, upregulate MAPK, inhibit NF-kb activation and inhibit FGF-2 export and may downregulate mTOR thereby inhibiting p70S6K and S6 protein expression. All of this may lead to an induction of apoptosis.
同义词

PBI05204; PBI 05204; PBI-05204; Oleandrin
通路

Autophagy
靶点

Autophagy
受体

Others
研究领域

Others-Field
适应症

——

CAS Number

465-16-7
分子量

576.72
分子式

C32H48O9
纯度

98%
溶解度

——
SMILES

CC1C(C(CC(O1)OC2CCC3(C(C2)CCC4C3CCC5(C4(CC(C5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O
化学全称

(3S,5R,9S,10S,13R,14S,16S)-14-hydroxy-3-(((2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-16-yl acetate

计算器

产品手册

关联产品

Sulfathiazole

Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug.
Cysteamine hydrochlo...

An agent for the treatment of nephropathic cystinosis and an antioxidant; increases intracellular glutathione levels in cystinotic cells, also increases the rates of apoptosis in cystinotic cells.
740 Y-P

740 Y-P is a potent and cell-permeable activator of PI3K.