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BMS-955176
CAS No. 1392312-45-6
BMS-955176 ( GSK-3532795 | BMS955176 )
产品货号. M11631 CAS No. 1392312-45-6
BMS-955176 (GSK-3532795) 是第二代 HIV-1 成熟抑制剂，对 gag/pr 重组病毒文库 (n=87) 表现出有效活性 (EC50=3.9±3.4 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7736 | 有现货 |
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| 50MG | ￥20898 | 有现货 |
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| 100MG | ￥27540 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称BMS-955176
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BMS-955176 (GSK-3532795) 是第二代 HIV-1 成熟抑制剂，对 gag/pr 重组病毒文库 (n=87) 表现出有效活性 (EC50=3.9±3.4 nM)。
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产品描述BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses; exhibits median EC50 of 21 nM toward a library of subtype B clinical isolates assayed in PBMCs; inhibits HIV-1 protease cleavage at the CA/SP1 junction within Gag in VLPs and in HIV-1-infected cells, and binds reversibly and with high affinity to assembled Gag in purified HIV-1 VLPs; has a greatly improved preclinical profile compared to that of Bevirimat.HIV Infection Phase 2 Clinical.
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体外实验GSK3532795 exhibits Kds of 3.2 ± 0.6, 4.3 ± 2.0, 6.5 ± 2.2 and 33.6 ± 5.9 nM for HIV WT, HIV V362I, HIV V370A, HIV ΔV370, respectively.
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体内实验——
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同义词GSK-3532795 | BMS955176
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通路Microbiology/Virology
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靶点HIV
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受体HIV
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研究领域Infection
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适应症HIV Infection
化学信息
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CAS Number1392312-45-6
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分子量691.03
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分子式C42H62N2O4S
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(=C)C1CCC2(C1C3CCC4C(C3(CC2)C)(CCC5C4(CC=C(C5(C)C)C6=CC=C(C=C6)C(=O)O)C)C)NCCN7CCS(=O)(=O)CC7
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化学全称Benzoic acid, 4-[17-[[2-(1,1-dioxido-4-thiomorpholinyl)ethyl]amino]-28-norlupa-2,20(29)-dien-3-yl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nowicka-Sans B, et al. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3956-69.
2. Regueiro-Ren A, et al. ACS Med Chem Lett. 2016 Apr 22;7(6):568-72.
3. Lin Z, et al. PLoS Pathog. 2016 Nov 28;12(11):e1005990.
产品手册
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