BFH-772 ( BFH772;BFH 772 )

产品货号. M16425 CAS No. 890128-81-1

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Datasheet

HNMR

HPLC

MSDS

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产品名称

BFH-772
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective and orally active VEGFR2 tyrosine kinase inhibitor with IC50 of 3 nM.
产品描述

A potent, selective and orally active VEGFR2 tyrosine kinase inhibitor with IC50 of 3 nM; shows 40-fold less potent activity B-RAF, RET and TIE-2, and >500-fold for FLK-1, FLT-1 and FLT-4; inhibits ligand-induced autophosphorylation of RET, PDGFR and KIT with IC50 of 30-160 nM, potently inhibits VEGF-driven angiogenesis in a chamber model and rodent tumor models at daily doses of less than 3 mg/kg.Psoriasis Phase 2 Discontinued
同义词

BFH772;BFH 772
通路

Angiogenesis
靶点

VEGFR
受体

VEGFR2
研究领域

Inflammation/Immunology
适应症

Psoriasis

CAS Number

890128-81-1
分子量

439.39
分子式

C23H16F3N3O3
纯度

>98% (HPLC)
溶解度

DMSO: 7.75 mg/mL
SMILES

O=C(C1=C2C=CC(OC3=NC=NC(CO)=C3)=CC2=CC=C1)NC4=CC=CC(C(F)(F)F)=C4
化学全称

1-Naphthalenecarboxamide, 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-

1. Bold G, et al. J Med Chem. 2016 Jan 14;59(1):132-46.

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产品手册

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