BAY8002

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BAY-8002 是一种有效的双重 MCT1/2 抑制剂（对大鼠 (C6)、人 (DLD-1) 和小鼠 (4T1) MCT1 的 IC50 值分别为 3、8 和 12 nM）。

BAY-8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3 8 and 12 nM at rat (C6) human (DLD-1) and mouse (4T1) MCT1 respectively).

BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 μM in EVSA-T cells).

BAY-8002 (80 and 160 mg/kg, p.o., twice daily, for more than 26 days) significantly inhibits tumor growth in Raji tumor-bearing mice. Animal Model:Female NOD SCID mice bearing Raji cells (7-10 weeks old) Dosage:80 and 160 mg/kg Administration:P.O. twice daily for more than 26 days Result:Inhibited tumor growth with no obvious body weight loss, but showed no effect on tumor regression.

BAY 8002 | BAY-8002

Membrane Transporter/Ion Channel

Monocarboxylate Transporter

MCT1

——

——

724440-27-1

415.85

C20H14ClNO5S

>98% (HPLC)

DMSO: 50 mg/mL (120.24 mM)

OC(=O)c1ccccc1NC(=O)c1cc(ccc1Cl)S(=O)(=O)c1ccccc1

2-(2-chloro-5-(phenylsulfonyl)benzamido)benzoic acid

(-20℃)

With Ice Pack

≥ 2 years