AR-C155858

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AR-C155858 是单羧酸转运蛋白 MCT1 和 MCT2 的抑制剂（Kis：2.3 nM 和 10 nM）。

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).(In Vitro):AR-C155858 (10 nM-100 nM) inhibits MCT1/MCT2 C-terminal chimaeras. AR-C155858 inhibits MCT1 expressed in Xenopus oocytes in a time- and concentration-dependent manner. AR-C155858 inhibits MCT2, and the 70% inhibition seen at 10 nM is followed by a gradually increasing inhibition which can only be explained by a Ki value of significantly less than 10 nM.

AR-C155858 (10 nM-100 nM) inhibits MCT1/MCT2 C-terminal chimaeras. AR-C155858 inhibits MCT2, and the 70% inhibition seen at 10 nM is followed by a gradually increasing inhibition which can only be explained by a Ki value of significantly less than 10 nM. AR-C155858 inhibits MCT1 expressed in Xenopus oocytes in a time- and concentration-dependent manner.

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Membrane Transporter/Ion Channel

Monocarboxylate Transporter

Apoptosis| VD/VDR

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496791-37-8

461.54

C21H27N5O5S

>98% (HPLC)

In Vitro:?DMSO : 70 mg/mL (151.67 mM)

CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(C(=O)N3C[C@H](O)CO3)c2c(=O)n(C)c1=O

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(-20℃)

With Ice Pack

≥ 2 years