AZD1283 ( AZD-1283; AZD1283; AZD 1283 )

产品货号. M17661 CAS No. 919351-41-0

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

AZD1283
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM).
产品描述

AZD1283 is a potent antagonist of the P2Y12 receptor. In a modified Folts model in dog, both AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 μg/kg/min. The doses that induced a larger than 3-fold increase in bleeding time were 33 μg/kg/min. Thus, the therapeutic index (TI) was ≥ 10. On the basis of these data, AZD1283 was progressed into human clinical trials as candidate drug.
同义词

AZD-1283; AZD1283; AZD 1283
通路

Angiogenesis
靶点

PDE
受体

P2Y12
研究领域

Cardiovascular Disease
适应症

——

CAS Number

919351-41-0
分子量

470.54
分子式

C23H26N4O5S
纯度

98%
溶解度

DMSO : 100 mg/mL. 212.52 mM;H2O : < 0.1 mg/mL
SMILES

CCOC(=O)c1c(nc(c(c1)C#N)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1)C
化学全称

ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate.

1. Bach P,et al. J Med Chem. 2013 Sep 12;56(17):7015-24.

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