Tadalafil ( IC351, IC-351, IC 351, Tadalafil, Adcirca, Cialis )

产品货号. M12614 CAS No. 171596-29-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Tadalafil
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Tadalafil is a potent phosphodiesterase-5 (PDE5) inhibitor (IC50=1 nM).
产品描述

Tadalafil is a potent phosphodiesterase-5 (PDE5) inhibitor (IC50=1 nM); no inhibition on most of the other families of PDEs, with the exception of PDE11.Sexual Dysfunction Approved
同义词

IC351, IC-351, IC 351, Tadalafil, Adcirca, Cialis
通路

Angiogenesis
靶点

PDE
受体

PDE5
研究领域

Endocrinology
适应症

Sexual Dysfunction

CAS Number

171596-29-5
分子量

389.40
分子式

C22H19N3O4
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 52 mg/mL
SMILES

O=C([C@@]1([H])CC2=C([C@@H](C3=CC(OCO4)=C4C=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O
化学全称

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-

1. Blount MA, et al. Mol Pharmacol, 2004, 66(1), 144-152.
2. Ring BJ, et al. Clin Pharmacol Ther, 2005, 77(1), 63-75.

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