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AZD-5153
CAS No. 1869912-39-9
AZD-5153 ( AZD5153 )
产品货号. M12890 CAS No. 1869912-39-9
AZD-5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AZD-5153
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AZD-5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.
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产品描述AZD-5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM; simultaneously binds to two bromodomains in BRD4; exhibits antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma.Blood Cancer Phase 1 Clinical
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同义词AZD5153
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通路Chromatin/Epigenetic
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靶点Bromodomain
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受体Bromodomain
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number1869912-39-9
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分子量479.59
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分子式C25H33N7O3
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1C(=O)N(CCN1CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5OC)C=C4)C
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化学全称(R)-4-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bradbury RH, et al. J Med Chem. 2016 Sep 8;59(17):7801-17.
2. Rhyasen GW, et al. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.
3. Collins TA, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Jun;6(6):357-364.
2. Rhyasen GW, et al. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.
3. Collins TA, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Jun;6(6):357-364.
产品手册
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