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ASP3026

CAS No. 1097917-15-1

ASP3026 ( ASP 3026;ASP-3026 )

产品货号. M10377 CAS No. 1097917-15-1

ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥284 有现货
5MG ¥437 有现货
10MG ¥640 有现货
25MG ¥1085 有现货
50MG ¥1604 有现货
100MG ¥2657 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    ASP3026
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively.
  • 产品描述
    ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively; also potently inhibits Ack, EGFR L858R, FRK and LTK with IC50 of 5-85 nM, inhibits the growth of NCI-H2228 cells with IC50 of 64.8 nM; enhances the antitumor activities of paclitaxel and pemetrexed without affecting body weight in mice model.Blood Cancer Phase 1 Discontinued
  • 同义词
    ASP 3026;ASP-3026
  • 通路
    Angiogenesis
  • 靶点
    ALK
  • 受体
    ALK
  • 研究领域
    Cancer
  • 适应症
    Blood cancer

化学信息

  • CAS Number
    1097917-15-1
  • 分子量
    580.70
  • 分子式
    C29H40N8O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    O=S(C1=CC=CC=C1NC2=NC=NC(NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3OC)=N2)(C(C)C)=O
  • 化学全称
    1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Mori M, et al. Mol Cancer Ther. 2014 Feb;13(2):329-40.
2. George SK, et al. Oncotarget. 2014 Jul 30;5(14):5750-63.
3. Mologni L, et al. Oncotarget. 2015 Mar 20;6(8):5720-34.
4. Iikubo K, et al. Chem Pharm Bull (Tokyo). 2018;66(3):251-262.
产品手册
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