ASP3026
CAS No. 1097917-15-1
ASP3026 ( ASP 3026;ASP-3026 )
产品货号. M10377 CAS No. 1097917-15-1
ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥284 | 有现货 |
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5MG | ¥437 | 有现货 |
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10MG | ¥640 | 有现货 |
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25MG | ¥1085 | 有现货 |
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50MG | ¥1604 | 有现货 |
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100MG | ¥2657 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称ASP3026
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively.
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产品描述ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8 nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively; also potently inhibits Ack, EGFR L858R, FRK and LTK with IC50 of 5-85 nM, inhibits the growth of NCI-H2228 cells with IC50 of 64.8 nM; enhances the antitumor activities of paclitaxel and pemetrexed without affecting body weight in mice model.Blood Cancer Phase 1 Discontinued
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同义词ASP 3026;ASP-3026
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通路Angiogenesis
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靶点ALK
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受体ALK
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number1097917-15-1
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分子量580.70
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分子式C29H40N8O3S
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=S(C1=CC=CC=C1NC2=NC=NC(NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3OC)=N2)(C(C)C)=O
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化学全称1,3,5-Triazine-2,4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mori M, et al. Mol Cancer Ther. 2014 Feb;13(2):329-40.
2. George SK, et al. Oncotarget. 2014 Jul 30;5(14):5750-63.
3. Mologni L, et al. Oncotarget. 2015 Mar 20;6(8):5720-34.
4. Iikubo K, et al. Chem Pharm Bull (Tokyo). 2018;66(3):251-262.
2. George SK, et al. Oncotarget. 2014 Jul 30;5(14):5750-63.
3. Mologni L, et al. Oncotarget. 2015 Mar 20;6(8):5720-34.
4. Iikubo K, et al. Chem Pharm Bull (Tokyo). 2018;66(3):251-262.
产品手册
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