ARV-471 ( —— )

产品货号. M28234 CAS No. 2229711-68-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

ARV-471
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ARV-471 is a best-in-class, orally active Cereblon -based estrogen receptor ( ER ) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
产品描述

ARV-471 is a best-in-class, orally active Cereblon -based estrogen receptor ( ER ) PROTAC degrader. ARV-471 is developed for the research of breast cancer.
同义词

——
通路

Endocrinology/Hormones
靶点

Estrogen Receptor/ERR
受体

nAChR
研究领域

——
适应症

——

CAS Number

2229711-68-4
分子量

723.9
分子式

C45H49N5O4
纯度

>98% (HPLC)
溶解度

——
SMILES

Oc1cc(CC[C@@H]([C@@H]2c(cc3)ccc3N3CCC(CN(CC4)CCN4c(cc4)cc(CN5[C@@H](CCC(N6)=O)C6=O)c4C5=O)CC3)c3ccccc3)c2cc1
化学全称

——

1.Matthew J. Cheesman . Oceania: Antidepressant Medicinal Plants. Herbal Medicine in Depression. 2016, 483-527.

计算器

产品手册

关联产品

Isopsoralenoside

Isopsoralenoside shows estrogen-like, osteoblastic proliferation accelerating, antitumor, and antibacterial effects.Psoralen (P), isopsoralen (IP), psoralenoside (PO) and Isopsoralenoside (IPO) are the major coumarins and coumarin-related benzofuran glycosides in Psoraleae Fructus, which have been reported to show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
WAY-200070

WAY-200070 is a potent, highly selective ERβ agonist with IC50 of 3 nM, displays 68-fold selectivity over ERα (IC50=260 nM).
PHTPP

A potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist.