1-Dodecylimidazole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

1-十二烷基咪唑 (N-十二烷基咪唑) 是一种溶酶体去污剂和细胞毒剂。 1-十二烷基咪唑通过其在溶酶体中的酸依赖性积累、溶酶体膜的破坏以及半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。

1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.(In Vitro):N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0.(In Vivo):The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats.

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Animal Model:Male ratsDosage:150 mg/kg body wt Administration:By stomach tube; daily for 10 days Result:Had significantly lower serum cholesterol concentrations than untreated animals.

N-Dodecylimidazole

GPCR/G Protein

Antibacterial

Drug Metabolite

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4303-67-7

236.403

C15H28N2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (423.01 mM)

CCCCCCCCCCCCn1ccnc1

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(-20℃)

With Ice Pack

≥ 2 years