TCS-PIM-1-4a ( SMI-4a | SMI4a | SMI 4a | TCS PIM-1 4a. )

产品货号. M18552 CAS No. 438190-29-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

TCS-PIM-1-4a
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

(Z)-SMI-4a 是一种选择性 ATP 竞争性 Pim-1 激酶抑制剂，IC50 为 21 nM。
产品描述

SMI-4a is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. SMI-4a was found to induce phosphorylation of extracellular signal-related kinase1/2 (ERK1/2), and the combination of SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor was highly synergistic in killing pre-T-LBL cells. SMI-4a may be developed as a therapeutic strategy for the treatment of pre-T-LBL.
体外实验

Western Blot Analysis Cell Line:HEK-293T cells Concentration:0.5 μM Incubation Time:1 hour Result:Caused a dose-dependent reduction in Pim-1-induced 4E-BP1 phosphorylation, with an IC50 of approximately 125 nM.
体内实验

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同义词

SMI-4a | SMI4a | SMI 4a | TCS PIM-1 4a.
通路

GPCR/G Protein
靶点

Antibacterial
受体

Pim1
研究领域

Cancer
适应症

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1. Beharry Z, et al. Mol Y Ther, 2009, 8(6), 1473-1483.

计算器

产品手册

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