GSK-729 ( GSK 729;GSK729 )

产品货号. M11073 CAS No. 1260243-45-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GSK-729
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM.
产品描述

A potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3; selectively pulls down EchA6 in a stereospecific manner in M. bovis BCG extracts, competes with CoA-binding, suppresses mycolic acid synthesis, and are bactericidal in mouse model of chronic tuberculosis infection.
同义词

GSK 729;GSK729
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

——
适应症

——

CAS Number

1260243-45-5
分子量

339.32
分子式

C16H16F3N3O2
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=C2N[C@H](C3=CC=C(CC)C=C3)C[C@H](C(F)(F)F)N2N=C1)O
化学全称

(5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

1. Cox JA, et al. Nat Microbiol. 2016 Jan 18;1:15006.

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产品手册

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