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(Z)-4-Hydroxytamoxifen

CAS No. 68047-06-3

(Z)-4-Hydroxytamoxifen ( trans-4-Hydroxytamoxifen )

产品货号. M15596 CAS No. 68047-06-3

A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥518 有现货
10MG ¥721 有现货
25MG ¥1596 有现货
50MG ¥3127 有现货
100MG ¥4609 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    (Z)-4-Hydroxytamoxifen
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium.
  • 产品描述
    A major metabolite of tamoxifen, a well-known Estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium; shows a 100-fold increased affinity for ER and approximately 100-times more potent than trans-tamoxifen in suppressing cell growth and plasminogen activator activity.
  • 同义词
    trans-4-Hydroxytamoxifen
  • 通路
    Endocrinology/Hormones
  • 靶点
    Estrogen Receptor/ERR
  • 受体
    ER
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    68047-06-3
  • 分子量
    387.51
  • 分子式
    C26H29NO2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 28 mg/mL
  • SMILES
    OC1=CC=C(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)\CC)C=C1
  • 化学全称
    Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Katzenellenbogen BS, et al. Cancer Res. 1984 Jan;44(1):112-9.
2. Desta Z, et al. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
3. Crewe HK, et al. Drug Metab Dispos. 2002 Aug;30(8):869-74.
产品手册
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  • Endoxifen

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