(R)-Terazosin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(R)-Terazosin 是 Terazosin 的活性 R-对映体。 (R)-Terazosin 是 α1-肾上腺素受体（α1a、α1b 和 α1d-肾上腺素受体，Ki 值分别为 6.51 nM、1.01 nM 和 1.97 nM）的有效拮抗剂。

(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively). (R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor(Ki of 3.85 μM, 0.33 μM and 0.37 μM, respectively). (R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues.(R)-Terazosin shows antagonism of at rat atrial α2B receptor (pEC30 : 5.69). (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor (pA2 of 7.5 and 5.31, respectively).(In Vitro):(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 3.85 μM, 0.33 μM and 0.37 μM, respectively.(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies.(In Vivo):(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 7.5 and 5.31, respectively.

(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 3.85 μM, 0.33 μM and 0.37 μM, respectively.(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies.

(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 7.5 and 5.31, respectively.

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Angiogenesis

Adrenergic Receptor

α1a-adrenoceptor|α1b-adrenoceptor |α1d-adrenoceptor

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109351-34-0

387.43

C19H25N5O4

>98% (HPLC)

DMSO:75 mg/mL (193.58 mM; Need ultrasonic)

COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)[C@H]1CCCO1

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(-20℃)

With Ice Pack

≥ 2 years