(R)-Equol
CAS No. 221054-79-1
(R)-Equol ( (+)-Equol )
产品货号. M26529 CAS No. 221054-79-1
(R)-Equol is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥284 | 有现货 |
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5MG | ¥462 | 有现货 |
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10MG | ¥786 | 有现货 |
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25MG | ¥1312 | 有现货 |
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50MG | ¥1928 | 有现货 |
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100MG | ¥2900 | 有现货 |
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200MG | ¥4277 | 有现货 |
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500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称(R)-Equol
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述(R)-Equol is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.
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产品描述(R)-Equol is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.(In Vitro):(R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) .(In Vivo):In Animals, (R)-Equol has a significantly reduced number of palpable tumors over time when compared with Controls (P=0.002).In addition, the number of palpable tumors formed by each rat in the (R)-Equol fed group was significantly lower than that of rats treated with S-(-)equol (P = 0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animals is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compared with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003) .
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同义词(+)-Equol
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体mPGES-1
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研究领域——
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适应症——
化学信息
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CAS Number221054-79-1
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分子量242.3
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分子式C15H14O3
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纯度>98% (HPLC)
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溶解度——
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SMILESOc1ccc(cc1)[C@@H]1COc2cc(O)ccc2C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Guerrero, M.D., Aquino, M., Bruno, I., et al. Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the γ-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal prostaglandin E synthase-1 expression. Journal of Medicinal Chemistry 50, 2176-2184 (2007).
产品手册
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