S6 Kinase
The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that mTOR/S6K signaling contributes to several pathological conditions, such as diabetes, cancer and obesity. mTOR (mammalian Target Of Rapamycin) is a protein kinase known to control cell growth in response to nutrients (amino acids), growth factors (insulin, IGF-1) and cellular energy (ATP), and acting as a sensor of nutrient availability in the cell. mTOR is present in the cell in two complexes, named mTORC1 and mTORC2. Once activated, mTORC1 is able to regulate several proteins, including two families of proteins: 4E-BPs (eukaryotic translation initiation factor 4E-binding protein) and S6Ks (ribosomal protein S6 kinase). S6K1 and S6K2 belong to the AGC kinase family.S6K1 and S6K2 share about 83% of identity in their kinase domains, which could justify the lack of interest on featuring consistently the S6K2 protein. AGC kinases are serine–threonine kinases that share some structural features and are implicated to regulate several cellular processes, such as growth, survival and metabolism. Besides S6Ks, proteins PKA, PKG, PKC and Akt, amongst others, are members of the AGC kinase family. Evidence show that the mTOR/S6K signaling pathway contributes to several diseases, such as cancer, diabetes and obesity.
References
1.Tavares MR,et al. Life Sci. 2015;131:1–10.
References
1.Tavares MR,et al. Life Sci. 2015;131:1–10.
PI3K/Akt/mTOR signaling
S6 Kinase
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FMK
产品货号 : M37951
cas no: 821794-92-7
FMK 是一种不可逆的 RSK2 抑制剂,能够共价修饰 RSK 的 C 末端区域。 -
MBM-55S
产品货号 : M26290
cas no: 2083624-07-9
MBM-55S 通过诱导细胞周期停滞和细胞凋亡来有效抑制癌细胞的增殖。 MBM-55S具有抗肿瘤活性,且对小鼠无明显毒性。 -
Gossypin
产品货号 : M24664
cas no: 652-78-8
棉酚具有抗糖尿病、抗氧化、抗惊厥、抗过敏、抗炎、镇痛、细胞毒和抗菌活性;它抑制 NF-kappaB 激活途径,这可能解释了它在抑制炎症、癌变和血管生成中的作用。 -
S6K-18
产品货号 : M22624
cas no: 1265789-88-5
S6K-18 是一种高选择性 S6K1 抑制剂,抑制 S6K1,IC50 为 52nM。 -
BIX 02565
产品货号 : M20148
cas no: 1311367-27-7
BIX 02565 是核糖体 S6 激酶 2 的有效抑制剂(RSK2,IC50:1.1 nM)。