FMK

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。

FMK is a an irreversible RSK2 kinase inhibitor, that covalently modifies the C-terminal kinase domain of RSK.

Pretreatment of ARVMs with 3 μM fmk attenuates the increase in Ser386 phosphorylation, but it has no inhibitory effect on the increase in Thr577 phosphorylation. FMK inhibits relatively few protein kinases in the panel, although it does inhibit protein tyrosine kinases, such as Src, Lck, Yes and Eph-A2, as well as S6K1. FMK will not inhibit RSK if the N-terminal kinase domain are activated by a mechanism that is independent of the C-terminal domain. Fmk potently inactivates the CTD auto-kinase activity of RSK1 and RSK2 with high specificity in mammalian cells. Targeting RSK2 by a specific small molecule RSK inhibitor fmk attenuates FGFR3-induced cytokine-independent growth in Ba/F3 cells. FMK inhibits cytokine-independent proliferation of Ba/F3 cells conferred by FGFR3.

——

——

PI3K/Akt/mTOR signaling

S6 Kinase

S6 Kinase

——

——

821794-92-7

342.37

C18H19FN4O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (146.04 mM; 超声助溶 )

Cc1ccc(cc1)-c1c(C(=O)CF)n(CCCO)c2ncnc(N)c12

——

(-20℃)

With Ice Pack

≥ 2 years