Flavonoids
Flavonoids are secondary polyphenolic metabolites occurring commonly in many fungi and plants. To the family of flavonoids belong several classes of compounds including anthoxanthins, in turn subdivided into two subgroups: flavones and flavonols; flavanones; flavanonols; flavans, in turn subdivided into three subgroups: flavan-3-ols, flavan-4-ols and flavan-3,4-diols; antocyanidins and isoflavonoids. The chemical structure of flavonoids is a 15-carbon skeleton which consist of two phenyl rings named A and B linked via a heterocyclic 4H-pyrane ring named C. Examples of known flavonoids are: Apigenin 1 and Quercetin 2 (antoxanthins: flavone and flavonol respectively); Naringenin 3 (flavanone); Taxifolin 4 (flavanonol); Catechin 5, Apiforol 6 and Leucocyanidin 7 (flavans: flavan-3-ol, flavan-4-ol and flavan-3,4-diol respectively); Malvidin 8 (anthocianidin) and Genistenin 9 (isoflavon). Flavonoids are also antiangiogenic agents through the regulation of the expression of VEGF, MMPs, EGFR and the inhibition of NFkB, PI3-K/AkT, ERK 1/2 signal pathways. This class of natural compounds is able to interfere in all the phases of cancer progression by modulating different enzymes and receptors involved in proliferation, differentiation, apoptosis, angiogenesis, metastasis and reverse multidrug resistance process.
References
1.Raffa D, et al. Eur J Med Chem. 2017;142:213–228.
References
1.Raffa D, et al. Eur J Med Chem. 2017;142:213–228.
Natural Products
Flavonoids
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Luteolinidin chloride
产品货号 : M21823
cas no: 1154-78-5
Luteolinidin 是一种天然脱氧花青素,从苔藓和蕨类植物中分离出来。 -
3',4',5',5,7-Pentamethoxyflavone
产品货号 : M21798
cas no: 53350-26-8
3',4',5',5,7-Pentamethoxyflavone 是从芸香科植物中提取的天然黄酮类化合物,通过抑制 Nrf2 途径使化疗耐药的癌细胞对化疗药物敏感。 -
Theaflavin-3-gallate
产品货号 : M21797
cas no: 30462-34-1
Theaflavin-3-gallate 是一种红茶茶黄素单体,被认为是红茶的重要生物学活性成分,具有健康益处。茶黄素-3-没食子酸酯充当氧化剂并在癌细胞中诱导氧化应激。 -
Chrysoeriol
产品货号 : M21732
cas no: 491-71-4
Chrysoeriol 是从热带植物 Coronopus didymus 中提取的天然黄酮类化合物,具有有效的抗氧化活性。 -
Eupatilin
产品货号 : M13588
cas no: 22368-21-4
Eupatilin (NSC 122413, Stillen) 是一种从蒿属植物中提取的具有药理活性的黄酮,具有抗炎、抗氧化和抗癌活性。