Thrombin
The main purpose of haemostasis, the formation of a blood clot composed of activated blood platelets intertwined with covalently linked fibrin, is arrest of bleeding from a damaged blood vessel. Thrombin is a multifunctional serine protease produced from prothrombin and is a key regulator in haemostatic and non-haemostatic processes. Thrombin activates platelets through PAR1 or -4, providing a procoagulant phospholipid membrane surface on which coagulation factors congregate. With multiple functions, thrombin is considered the central enzyme in coagulation. Not only does thrombin convert fibrinogen into fibrin, it enhances its own generation through activation of the cofactors V and VIII as well as factor XI in the so-called feedback loop. Through activation of factor XIII, thrombin stimulates covalent crosslinking of fibrin molecules. Thrombin attenuates its own generation through activation of the protein C pathway, in which thrombomodulin bound thrombin activates protein C on the endothelial protein C receptor.1.Posma JJ, et al. J Thromb Haemost. 2016;14(10):1908–1916.
Autophagy
Thrombin
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Imitrodast
产品货号 : M36182
cas no: 114686-12-3
Imitrodast is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor for the treatment of immune system disorders, respiratory disorders, and cardiovascular diseases, and can be used in studies of arterial thrombosis, asthma, and coronary vasospasm. -
Naroparcil
产品货号 : M36130
cas no: 120819-70-7
Naroparcil, an orally available thioglycoside analog of 4-methylumbelliferyl β-D-xyloside, showed antithrombotic effects in the Wessler sludge model of venous thrombosis (jugular vein).Naroparcil enhanced the formation of the thrombin/heparin cofactor II complex, induced dermatophyte sulfate-like substances in plasma from treated rabbits appearance, but reduced the formation of thrombin/antithrombin III complexes in plasma incubated with (125I)-human alpha-thrombin. -
Pirodomast
产品货号 : M36113
cas no: 108310-20-9
Pirodomast is a thromboxane A (TXA2) synthase inhibitor. Pirodomast inhibits leukotriene (LT) D4, C4, E4 formation and thromboxane B2 (TXB2) activity, but is weakly or ineffectively antagonistic to guinea pig bronchospasm induced by histamine, methacholine, serotonin, LTC4, or platelet-activating factor. -
Protamine sulfate
产品货号 : M35246
cas no: 9009-65-8
Protamine sulfate 是一个阳性离子肽,具有抗肝素活性,可以中和肝素的抗凝血作用,增强脂质介导的基因转移。 -
H-Gly-Arg-pNA dihydrochloride
产品货号 : M34903
cas no: 125455-61-0
H-Gly-Arg-pNA dihydrochloride (H-Gly-Arg-Pna 2HCl) belongs to the class of peptides that bind to 1,2 thrombin and can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.